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1

Pharmacogenetics-Based Population Pharmacokinetic Analysis of Efavirenz in HIV-1-Infected Individuals

Arab-Alameddine, M, Di Iulio, J, Buclin, T, Rotger, M, Lubomirov, R, Cavassini, M, Fayet, A, Décosterd, LA, Eap, CB, Biollaz, J

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 1.82 MB

english, 2009

2

Superficial Ca2+stores are involved in the effect of thyrotropin-releasing hormone on the KCachannel activity in smooth muscle cells of the gastric fundus

P. S. Petkova-Kirova, L. T. Lubomirov, H. S. Gagov, V. Kolev, D. B. Duridanova

Journal:

Neurophysiology

Year:

2000

Language:

english

File:

PDF, 215 KB

english, 2000

3

Outcome trials of COX-2 selective inhibitors: global safety evaluation does not promise benefits

Jorge Gomez Cerezo, Rubin Lubomirov Hristov, Antonio J. Carcas Sansuán, Juan J. Vázquez Rodríguez

Journal:

European Journal of Clinical Pharmacology

Year:

2003

Language:

english

File:

PDF, 187 KB

english, 2003

4

Corticotropin-releasing hormone acts on guinea pig ileal smooth muscle via protein kinase A

D. B. Duridanova, P. S. Petkova-Kirova, L. T. Lubomirov, H. Gagov, K. Boev

Journal:

Pflügers Archiv European Journal of Physiology

Year:

1999

Language:

english

File:

PDF, 149 KB

english, 1999

5

Regulation of the crossbridge cycle in vascular smooth muscle by cAMP signalling

G. Pfitzer, L. T. Lubomirov, K. Reimann, H. Gagov, R. Schubert

Journal:

Journal of Muscle Research and Cell Motility

Year:

2006

Language:

english

File:

PDF, 285 KB

english, 2006

6

Distribution of CAG repeats in normal. and Huntington's disease patients in Israel

E. Gazit, L. Lubomirov, O. Munakov, A. Topper, M. Frydman, K. Fried, Z. Borochovitz, N. Dangoor, A. Bogolubou, HJA Carp

Journal:

Clinical Genetics

Year:

1998

Language:

english

File:

PDF, 152 KB

english, 1998

7

Ghrelin signalling in guinea-pig femoral artery smooth muscle cells

M. I. Mladenov, K. L. Hristov, D. Z. Dimitriova, R. Schubert, L. T. Lubomirov, I. K. Gjorgoski, D. B. Duridanova, H. S. Gagov

Journal:

Acta Physiologica

Year:

2008

Language:

english

File:

PDF, 651 KB

english, 2008

8

Urocortin relaxes rat tail arteries by a PKA-mediated reduction of the sensitivity of the contractile apparatus for calcium

Lubomir Lubomirov, Hristo Gagov, Polina Petkova-Kirova, Dessislava Duridanova, Vjatscheslav U Kalentchuk, Rudolf Schubert

Journal:

British Journal of Pharmacology

Year:

2001

Language:

english

File:

PDF, 172 KB

english, 2001

9

Cocaine- and amphetamine-regulated transcript (CART) peptide as an in vivo regulator of cardiac function in Rana ridibunda frog

Iliyana V. Ivanova, Rudolf Schubert, Dessislava B. Duridanova, Thomas B. Bolton, Lubomir T. Lubomirov, Hristo S. Gagov

Journal:

Experimental Physiology

Year:

2007

Language:

english

File:

PDF, 194 KB

english, 2007

10

Urocortin increases the intracellular cAMP concentration and thus decreases the degree of phosphorylation of MYPT1 and increases the myosin phosphatase activity

L. T. Lubomirov, R. Schubert, H. S. Gagov, D. B. Duridanova, G. Pfitzer

Journal:

Year:

2006

Language:

english

File:

PDF, 316 KB

english, 2006

11

An Acenocoumarol Dosing Algorithm Using Clinical and Pharmacogenetic Data in Spanish Patients with Thromboembolic Disease

Borobia, Alberto M., Lubomirov, Rubin, Ramírez, Elena, Lorenzo, Alicia, Campos, Armando, Muñoz-Romo, Raul, Fernández-Capitán, Carmen, Frías, Jesús, Carcas, Antonio J., Gong, Yan

Journal:

Year:

2012

Language:

english

File:

PDF, 120 KB

english, 2012

12

Conceptos generales y métodos de estudio en farmacogenética

Rubin Lubomirov, Amalio Telenti, Margalida Rotger

Journal:

Enfermedades Infecciosas y Microbiología Clínica

Year:

2008

File:

PDF, 304 KB

2008

13

Regulation of Smooth Muscle Contraction by Small GTPases

Puetz, S., Lubomirov, L. T., Pfitzer, G.

Journal:

News in Physiological Sciences

Year:

2009

Language:

english

File:

PDF, 639 KB

english, 2009

14

New insights into myosin phosphorylation during cyclic nucleotide-mediated smooth muscle relaxation

Sandra Puetz, Mechthild M. Schroeter, Heike Piechura, Lena Reimann, Mona S. Hunger, Lubomir T. Lubomirov, Doris Metzler, Bettina Warscheid, Gabriele Pfitzer

Journal:

Journal of Muscle Research and Cell Motility

Year:

2012

Language:

english

File:

PDF, 542 KB

english, 2012

15

Functional remodelling of arterial endothelium during early postnatal development in rats

Gaynullina, D., Lubomirov, L. T., Sofronova, S. I., Kalenchuk, V. U., Gloe, T., Pfitzer, G., Tarasova, O. S., Schubert, R.

Journal:

Cardiovascular Research

Year:

2013

Language:

english

File:

PDF, 527 KB

english, 2013

16

Contribution of Genetic Background, Traditional Risk Factors, and HIV-Related Factors to Coronary Artery Disease Events in HIV-Positive Persons

Rotger, M., Glass, T. R., Junier, T., Lundgren, J., Neaton, J. D., Poloni, E. S., van 't Wout, A. B., Lubomirov, R., Colombo, S., Martinez, R., Rauch, A., Gunthard, H. F., Neuhaus, J., Wentworth, D.,

Journal:

Clinical Infectious Diseases

Year:

2013

Language:

english

File:

PDF, 504 KB

english, 2013

17

PP130—Evaluation of the influence of cytocrome P450 oxidoreductase (POR) in the stable dose of acenocoumarol

Borobia, A.M., Tong, H.Y., Lubomirov, R., Almeida-Paulo, G.N., Zegarra, C., Frias, J., Carcas, A.J.

Journal:

Clinical Therapeutics

Year:

2013

Language:

english

File:

PDF, 56 KB

english, 2013

18

PP127—CYP4F2 and apoe contribution in acenocoumarol dosing based on genotype: A comparison of two algorithms

Tong, H.Y., Borobia, A.M., Lubomirov, R., Zegarra, C., Lei, S.H., Frías, J., Carcas, A.J.

Journal:

Clinical Therapeutics

Year:

2013

Language:

english

File:

PDF, 80 KB

english, 2013

19

PP132—Contribution of genetic (CYP3A5, ABCB1 and POR) and non-genetic variables to the oral tacrolimus clearance in children’s with stable kidney transplant, during advagraf® treatment

Almeida-Paulo, G.N., Lubomirov, R., Alonso-Sanchez, N.L., Espinosa, L., Carcas, A.J.

Journal:

Clinical Therapeutics

Year:

2013

Language:

english

File:

PDF, 69 KB

english, 2013

20

Population pharmacokinetic modelling and evaluation of different dosage regimens for darunavir and ritonavir in HIV-infected individuals

Arab-Alameddine, M., Lubomirov, R., Fayet-Mello, A., Aouri, M., Rotger, M., Buclin, T., Widmer, N., Gatri, M., Ledergerber, B., Rentsch, K., Cavassini, M., Panchaud, A., Guidi, M., Telenti, A., Decost

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2014

Language:

english

File:

PDF, 338 KB

english, 2014

21

Limited sampling strategies for tacrolimus exposure (AUC 0-24 ) prediction after Prograf ® and Advagraf ® administration in children and adolescents with liver or kidney transplants

Almeida-Paulo, Gonzalo N., Lubomirov, Rubin, Alonso-Sanchez, Nazareth Laura, Espinosa-Román, Laura, Fernández Camblor, Carlota, Díaz, Carmen, Muñoz Bartola, Gema, Carcas-Sansuán, Antonio J.

Journal:

Transplant International

Year:

2014

Language:

english

File:

PDF, 230 KB

english, 2014

22

Inhibition of corticotropin-releasing factor CRH-R2 receptors in smooth muscle cells

Duridanova, Dessislava, Kolev, Vladislav, Lubomirov, Lubomir, Penchev, Plamen, Staikov, Ivan, Gurkov, Pancho

Journal:

Expert Opinion on Therapeutic Targets

Year:

1998

Language:

english

File:

PDF, 41 KB

english, 1998

23

Neonatal mouse ileum: functional properties and protein composition of the contractile machinery

Eifinger, Frank, Lubomirov, Lubomir T., Dercks, Elena, Genchev, Borislav, Roth, Bernhard, Neiss, Wolfram F., Pfitzer, Gabriele, Schroeter, Mechthild M.

Journal:

Pediatric Research

Year:

2014

Language:

english

File:

PDF, 3.17 MB

english, 2014

24

Thromboxane A2-induced Bi-directional Regulation of Cerebral Arterial Tone

Neppl, R. L., Lubomirov, L. T., Momotani, K., Pfitzer, G., Eto, M., Somlyo, A. V.

Journal:

Journal of Biological Chemistry

Year:

2009

Language:

english

File:

PDF, 1.45 MB

english, 2009

25

Population Pharmacokinetic Analysis and Pharmacogenetics of Raltegravir in HIV-Positive and Healthy Individuals

Arab-Alameddine, M., Fayet-Mello, A., Lubomirov, R., Neely, M., di Iulio, J., Owen, A., Boffito, M., Cavassini, M., Gunthard, H. F., Rentsch, K., Buclin, T., Aouri, M., Telenti, A., Decosterd, L. A.,

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2012

Language:

english

File:

PDF, 698 KB

english, 2012

26

A new monoclinic polymorph of dichloridotetrakis(dimethyl sulfoxide)ruthenium(II)

Georgieva, Gergana, Gencheva, Galina, Shivachev, Boris Lubomirov, Nikolova, Rosica Petrova

Journal:

Acta Crystallographica Section E Structure Reports Online

Year:

2008

Language:

english

File:

PDF, 788 KB

english, 2008

27

Genetic polymorphisms of CYP1A2, CYP3A4, CYP3A5, pregnane/steroid X receptor and constitutive androstane receptor in 207 healthy Spanish volunteers

Oliver, Paloma, Lubomirov, Rubin, Carcas, Antonio

Journal:

Clinical Chemistry and Laboratory Medicine

Year:

2010

Language:

english

File:

PDF, 72 KB

english, 2010

28

Urocortin-Induced Decrease in Ca2+ Sensitivity of Contraction in Mouse Tail Arteries Is Attributable to cAMP-Dependent Dephosphorylation of MYPT1 and Activation of Myosin Light Chain Phosphatase

Lubomirov, L. T.

Journal:

Circulation Research

Year:

2006

Language:

english

File:

PDF, 764 KB

english, 2006

29

AMPK Dilates Resistance Arteries via Activation of SERCA and BKCa Channels in Smooth Muscle

Schneider, H., Schubert, K. M., Blodow, S., Kreutz, C.-P., Erdogmus, S., Wiedenmann, M., Qiu, J., Fey, T., Ruth, P., Lubomirov, L. T., Pfitzer, G., Mederos y Schnitzler, M., Hardie, D. G., Gudermann,

Journal:

Year:

2015

Language:

english

File:

PDF, 1.44 MB

english, 2015

30

Association of Pharmacogenetic Markers with Premature Discontinuation of First-line Anti-HIV Therapy: An Observational Cohort Study

Lubomirov, R., Colombo, S., di Iulio, J., Ledergerber, B., Martinez, R., Cavassini, M., Hirschel, B., Bernasconi, E., Elzi, L., Vernazza, P., Furrer, H., Gunthard, H. F., Telenti, A.

Journal:

The Journal of Infectious Diseases

Year:

2011

Language:

english

File:

PDF, 334 KB

english, 2011

31

Pharmacogenetic Implementation In The Routine Clinical Practice: Design of A Multicenter Pilot Clinical Trial

Borobia, A.M., Lubomirov, R., Abad, F., Tong, H.Y., Ramírez, E., Frías, J., Carcas, A.J.

Journal:

Clinical Therapeutics

Year:

2015

Language:

english

File:

PDF, 61 KB

english, 2015

32

Implementing Pharmacogenetics: Pharmarray® And Pharmacogenetic Consultation

Borobia, A.M., Lubomirov, R., Tong, H.Y., Arias, P., Tenorio, J., Frías, J., Lapunzina, P., Carcas, A.J.

Journal:

Clinical Therapeutics

Year:

2015

Language:

english

File:

PDF, 48 KB

english, 2015

33

Cytochrome P450 Oxidoreductase Contribution On An Acenocoumarol Dosing Algorithm

Tong, H.Y., Borobia, A.M., Lubomirov, R., Hernández, R., Muñoz, M., Ramírez, E., Frías, J., Carcas, A.J.

Journal:

Clinical Therapeutics

Year:

2015

Language:

english

File:

PDF, 46 KB

english, 2015

34

Screening and Recruitment Procedures of Healthy Volunteers In A Phase I Clinical Trial Unit: Experience In 64 Bioequivalence Studies

Duque, B., Borobia, A.M., Lubomirov, R., Ramirez, E., Guerra, P., Medrano, N., Tong, H.Y., Carcas, A.J., Frías, J.

Journal:

Clinical Therapeutics

Year:

2015

Language:

english

File:

PDF, 49 KB

english, 2015

35

A Preliminary Model to Avoid the Overestimation of Sample Size in Bioequivalence Studies

Ramírez, E., Abraira, V., Guerra, P., Borobia, A., Duque, B., López, J., Mosquera, B., Lubomirov, R., Carcas, A., Frías, J.

Journal:

Year:

2013

Language:

english

File:

PDF, 256 KB

english, 2013

36

Phase 1 study of two inodilators in neonates undergoing cardiovascular surgery

Pellicer, Adelina, Riera, Joan, Lopez-Ortego, Paloma, Bravo, María Carmen, Madero, Rosario, Perez-Rodriguez, Jesús, Labrandero, Carlos, Quero, Jose, Buño, Antonio, Castro, Luis, Lubomirov, Rubin, Caba

Journal:

Pediatric Research

Year:

2013

Language:

english

File:

PDF, 489 KB

english, 2013

37

ADME pathway approach for pharmacogenetic studies of anti-HIV therapy

Lubomirov, Rubin, Csajka, Chantal, Telenti, Amalio

Journal:

Pharmacogenomics

Year:

2007

Language:

english

File:

PDF, 414 KB

english, 2007

38

Uam Course on Good Clinical Practice (Gcps) for Investigators: A 3 Years Experience

Duque, B., Borobia, A.M., Lubomirov, R., Ramirez, E., Guerra, P., Medrano, N., Tong, H.Y., Carcas, A.J., Frías, J.

Journal:

Clinical Therapeutics

Year:

2015

Language:

english

File:

PDF, 49 KB

english, 2015

39

Aging-related alterations in eNOS and nNOS responsiveness and smooth muscle reactivity of murine basilar arteries are modulated by apocynin and phosphorylation of myosin phosphatase targeting subunit-1

Lubomirov, L. T., Papadopoulos, S., Pu tz, S., Welter, J., Klo ckener, T., Weckmu ller, K., Ardestani, M. A., Filipova, D., Metzler, D., Metzner, H., Staszewski, J., Zittrich, S., Gagov, H., Schroeter

Journal:

Journal of Cerebral Blood Flow and Metabolism

Year:

2016

Language:

english

File:

PDF, 1.02 MB

english, 2016

40

Contribution of CYP2B6 alleles in explaining extreme (S)-methadone plasma levels

Dobrinas, Maria, Crettol, Séverine, Oneda, Beatrice, Lahyani, Rachel, Rotger, Margalida, Choong, Eva, Lubomirov, Rubin, Csajka, Chantal, Eap, Chin B.

Journal:

Pharmacogenetics and Genomics

Year:

2013

Language:

english

File:

PDF, 540 KB

english, 2013

41

In vivo analysis of efavirenz metabolism in individuals with impaired CYP2A6 function

Iulio, Julia di, Fayet, Aurélie, Arab-Alameddine, Mona, Rotger, Margalida, Lubomirov, Rubin, Cavassini, Matthias, Furrer, Hansjakob, Günthard, Huldrych F., Colombo, Sara, Csajka, Chantal, Eap, Chin B.

Journal:

Pharmacogenetics and Genomics

Year:

2009

Language:

english

File:

PDF, 319 KB

english, 2009

42

A Sport-Specific Upper-Body Ergometer Test for Evaluating Submaximal and Maximal Parameters in Elite Rock Climbers

Michailov, Michail Lubomirov, Morrison, Audry, Ketenliev, Mano Mitkov, Pentcheva, Boyanka Petkova

Journal:

International Journal of Sports Physiology and Performance

Year:

2015

Language:

english

File:

PDF, 226 KB

english, 2015

43

Weight of ABCB1 and POR genes on oral tacrolimus exposure in CYP3A5 nonexpressor pediatric patients with stable kidney transplant

Almeida-Paulo, G N, Dapía García, I, Lubomirov, R, Borobia, A M, Alonso-Sánchez, N L, Espinosa, L, Carcas-Sansuán, A J

Journal:

The Pharmacogenomics Journal

Year:

2017

Language:

english

File:

PDF, 298 KB

english, 2017

44

Src tyrosine kinases contribute to serotonin-mediated contraction by regulating calcium-dependent pathways in rat skeletal muscle arteries

Zavaritskaya, Olga, Lubomirov, Lubomir T., Altay, Serdar, Schubert, Rudolf

Journal:

Pflügers Archiv European Journal of Physiology

Year:

2017

Language:

english

File:

PDF, 730 KB

english, 2017

45

The AMP-Related Kinase (AMPK) Induces Ca 2+ -Independent Dilation of Resistance Arteries by Interfering with Actin Filament Formation

Schubert, Kai M, Qiu, Jiehua, Blodow, Stephanie, Wiedenmann, Margarethe, Lubomirov, Lubomir T, Pfitzer, Gabriele, Pohl, Ulrich, Schneider, Holger

Journal:

Circulation Research

Year:

2017

Language:

english

File:

PDF, 3.30 MB

english, 2017

46

Influence of two variants of CYP450 oxidoreductase on the stable dose of acenocoumarol in a Spanish population

Tong, Hoi Y, Borobia, Alberto M, Martínez Ávila, José Carlos, Lubomirov, Rubin, Muñoz, Mario, Blanco Bañares, María J, Hernández, Rafael, Fernández Capitán, Carmen, Ramírez, Elena, Frías, Jesús, Carca

Journal:

Pharmacogenomics

Year:

2017

Language:

english

File:

PDF, 1022 KB

english, 2017

47

Ribbon-like foldamers for cellular uptake and drug delivery

Amblard, Muriel Christiane, Vezenkov, Lubomir Lubomirov, Martin, Vincent, Bettache, Nadir, Simon, Matthieu, Messerschmitt, Alexandre, Legrand, Baptiste, Bantignies, Jean-Louis, Subra, Gilles, Maynadie

Journal:

Year:

2017

Language:

english

File:

PDF, 1.64 MB

english, 2017

48

Reliability and Validity of Finger Strength and Endurance Measurements in Rock Climbing

Michailov, Michail Lubomirov, Baláš, Jiří, Tanev, Stoyan Kolev, Andonov, Hristo Stoyanov, Kodejška, Jan, Brown, Lee

Journal:

Research Quarterly for Exercise and Sport

Year:

2018

Language:

english

File:

PDF, 1.43 MB

english, 2018

49

The involvement of phosphorylation of myosin phosphatase targeting subunit1 (MYPT1) and MYPT1 isoform expression in NO/cGMP mediated differential vasoregulation of cerebral arteries compared to systemic arteries

Lubomirov, Lubomir T., Papadopoulos, Symeon, Filipova, Dilyana, Baransi, Sufian, Todorović, Daniel, Lake, Philipp, Metzler, Doris, Hilsdorf, Silvia, Schubert, Rudolf, Schroeter, Mechthild M., Pfitzer,

Journal:

Acta Physiologica

Year:

2018

Language:

english

File:

PDF, 2.32 MB

english, 2018

50

159 Pharmacokinetics (PKS) of Levosimendan (LEVO) and Intermediate Metabolites (OR-1855 and OR-1896) in Newborns Undergoing Cardiovascular Surgery with Cardiopulmonary Bypass (CPB)

Pellicer, A., Lubomirov, R., Bravo, M., Lopez-Ortego, P., Perez-Rodriguez, J., Quero, J., Cabanas, F.

Journal:

Archives of Disease in Childhood

Year:

2012

Language:

english

File:

PDF, 591 KB

english, 2012